Mean 300 ml addition yields better results than mean 227 ml 
Courcoulas published results of 255 patients in a randomized controlled study (modified intention to treat). The patients achieved 10% TBL (loss of 10% of initial weight). Notice that the weight regain begins at 4-5 months – that is 1-2 months prior to Orbera balloon removal. This means that balloon effect diminishes and weight regain begins already at 4-5 months. This is most likely true of all balloons.
A published study of the Orbera balloon reviewed over 600 balloons that remained implanted beyond six months and up to 14 months. The publication concluded as follows:“Conclusion: Extending the duration of BIB(Orbera)) use up to 14 months safely maintains weight loss…” However, significant extra weight loss beyond six months was not achieved. This proves the point that extending implantation beyond six months does not achieve extra weight loss. With the Spatz adjustable balloon, the extended implantation time, in combination with adjustment, has been shown to increase weight loss and responder rates.